Ativan

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Ativan Medicine

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Shelf life

12 months

Incompatibilities

None known

List of excipients

Polyethylene glycol 400

Benzyl alcohol

Propylene glycol

Preclinical safety data

Nothing of relevance to the prescriber.

Pharmacodynamic properties

Ativan is a benzodiazepine with anxiolytic, sedative, hypnotic, anticonvulsant and muscle relaxant properties.

Pharmacokinetic properties

Ativan Injection is readily absorbed when given intramuscularly. Peak plasma concentrations occur approximately 60-90 minutes following intramuscular administration.

Ativan is metabolised by a simple one-step process to a pharmacologically inactive glucuronide. There is minimal risk of accumulation after repeated doses, giving a wide margin of safety.

There are no major active metabolites. The elimination half-life is about 12-16 hours when given intramuscularly or intravenously.

Date of revision of the text

05/2014

Marketing authorisation holder

Pfizer Limited

Ramsgate Road

Sandwich

Kent,

CT13 9NJ

United Kingdom

Special precautions for storage

Store and transport refrigerated (2°C to 8°C).

Keep ampoule in the outer carton.

Nature and contents of container

1ml solution in 2ml ampoules (Type I glass) with a one-point-cut opening, position marked by red spot in pack sizes of 10.

Marketing authorisation number(s)

PL 00057/1279

Special precautions for disposal and other handling

None.

Date of first authorisation/renewal of the authorisation

11 August 2011