Ativan

Shelf life

12 months

Incompatibilities

None known

List of excipients

Polyethylene glycol 400

Benzyl alcohol

Propylene glycol

Preclinical safety data

Nothing of relevance to the prescriber.

Pharmacodynamic properties

Ativan is a benzodiazepine with anxiolytic, sedative, hypnotic, anticonvulsant and muscle relaxant properties.

Pharmacokinetic properties

Ativan Injection is readily absorbed when given intramuscularly. Peak plasma concentrations occur approximately 60-90 minutes following intramuscular administration.

Ativan is metabolised by a simple one-step process to a pharmacologically inactive glucuronide. There is minimal risk of accumulation after repeated doses, giving a wide margin of safety.

There are no major active metabolites. The elimination half-life is about 12-16 hours when given intramuscularly or intravenously.

Date of revision of the text

05/2014

Marketing authorisation holder

Pfizer Limited

Ramsgate Road

Sandwich

Kent,

CT13 9NJ

United Kingdom

Special precautions for storage

Store and transport refrigerated (2°C to 8°C).

Keep ampoule in the outer carton.

Nature and contents of container

1ml solution in 2ml ampoules (Type I glass) with a one-point-cut opening, position marked by red spot in pack sizes of 10.

Marketing authorisation number(s)

PL 00057/1279

Special precautions for disposal and other handling

None.

Date of first authorisation/renewal of the authorisation

11 August 2011