Hypersensitivity.
Inhibition of the function of the pancreatic insulin apparatus (with prolonged use).
Beriberi and hypovitaminosis C, hemorrhagic diathesis, bleeding (nasal, pulmonary, hepatic, uterine, caused by radiation sickness), overdose of anticoagulants, infectious diseases and intoxication, Addison's disease, nephropathy of pregnant women, sluggish healing wounds and bone fractures, dystrophy, mental and physical stress.
Participates in the regulation of carbohydrate metabolism, redox processes, blood clotting, capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.
At a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life of the drug Ascorbic acid with glucoselyophilizate for the preparation of a solution for intravenous and intramuscular administration of 0.05 g — 2 years.
tablets 100 mg 877 mg 100 mg 877 — 1 year.
dragee 50 mg — 1.5 years.
Do not use after the expiration date indicated on the package.
Instructions for medical useAscorbic acid with glucose
Instructions for medical use-RU No. LP-001199
Last modified date: 11.11.2011
Dosage formPills
Composition1 tablet contains:
Active substance :
Ascorbic acid 100 mg, dextrose (glucose) monohydrate 877 mg.
Excipients :
Calcium stearate-10 mg, talc-13 mg.
Description of the dosage formTablets are white, flat-cylindrical, round, with a chamfer and a risk.
Pharmacological GroupVitamin C
Pharmacological actionAscorbic acid plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and increases the body's resistance to infections.
Dextrose (glucose) is involved in various metabolic processes in the body.
IndicationsPrevention and treatment of hypo-and beriberi (scurvy). Ensuring the increased demand of the body for vitamin C during intensive growth, pregnancy, breast-feeding, during intense physical and mental stress, stressful conditions, during recovery after long-term serious diseases.
ContraindicationsHypersensitivity to the drug. Do not prescribe large doses to patients with increased blood clotting, thrombophlebitis and a tendency to thrombosis, diabetes mellitus and conditions accompanied by an increased blood glucose content. Contraindicated in children under 6 years of age.
With caution
Diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, for use in high doses-hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolithiasis.
Use during pregnancy and lactationAscorbic acid penetrates the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop ascorbic disease as a withdrawal reaction. Therefore, during pregnancy, ascorbic acid should not be taken in increased doses, except in cases where the expected benefit exceeds the potential risk.
Ascorbic acid is excreted in breast milk. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent deficiency in an infant. It is recommended that the nursing mother does not exceed the maximum daily requirement for ascorbic acid, except in cases where the expected benefit exceeds the potential risk.
Method of administration and dosageThe drug is taken orally after eating.
For prophylactic purposes, adults take ½ (50 mg) - 1 (100 mg) tablet, children from 6 to 18 years of age take ½ (50 mg) tablets per day.
For medicinal purposes, adults take ½ (50 mg) - 1 (100 mg) tablet 3-5 times a day, children take ½ (50 mg) - 1 (100 mg) 2-3 times a day.
The duration of treatment depends on the nature and course of the disease.
During pregnancy and lactation, 3 tablets a day for 10-15 days, then 1 tablet a day.
Side effectsAllergic reactions, irritation of the gastrointestinal mucosa (nausea, vomiting, diarrhea, spasm of the gastrointestinal tract), inhibition of the function of the pancreatic insulin apparatus (hyperglycemia, glucosuria): when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate).
Changes in laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
OverdoseSymptoms: when used more than 1 g - headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa, suppression of the function of the pancreatic insulin apparatus (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg/day).
Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microvascular complications).
In the case of ingestion of a potentially toxic dose, vomiting is caused, in rare cases, the stomach is washed, activated charcoal is prescribed, laxatives (for example, an isotonic solution of sodium sulfate).
InteractionAscorbic acid: increases the concentration of benzylpenicillin and tetracyclines in the blood, at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that which is part of oral contraceptives).
Improves the absorption of iron preparations in the intestine (converts trivalent iron to divalent), can increase the excretion of iron when used simultaneously with deferoxamine.
Reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid, oral contraceptives, fresh juices, and alkaline drinks reduce absorption and absorption.
When used simultaneously with acetylsalicylic acid, the urinary excretion of ascorbic acid increases and the excretion of acetylsalicylic acid decreases. Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
Drugs of the quinoline series, calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the reserves of ascorbic acid. When used simultaneously, it reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, the disulfiram - ethanol interaction may be disrupted.
In high doses, it increases the excretion of mexiletin by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, tubular reabsorption of amphetamine and tricyclic antidepressants.
Special instructionsDue to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure.
With prolonged use of large doses, it is possible to inhibit the function of the pancreatic insulin apparatus, so it should be regularly monitored during treatment.
In patients with high iron content in the body, ascorbic acid should be used in minimal doses.
The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors may aggravate the course of the process.
Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, the activity of "liver" transaminases and lactate dehydrogenase).
Information about the possible effect of a medicinal product for medical use on the ability to drive vehicles, mechanisms
It does not affect the ability to drive vehicles and work with other mechanical means.
Release formTablets (100 mg 877 mg).
10 tablets in a contour cell-free package or in a contour cell package. 1, 2, 5 contour cell or contour cell-free packages with instructions for use are placed in a pack. Contour cell-free packages are placed in a group package with an equal number of instructions for use.
Storage conditionsIn a place protected from light, at a temperature not exceeding 25°C.
Keep out of reach of children.
Expiration date1 year.
Do not use after the expiration date.
Conditions of supply of pharmaciesWithout a doctor's prescription.
Аскорбиновая кислота с глюкозой - инструкция по медицинскому применению - РУ № ЛП-000311 от 2018-03-121 ampoule with lyophilized powder for the preparation of an injection solution contains 0.05 g of ascorbic acid, complete with water for injection, in ampoules of 2 ml, in a package of 5 sets.
In / m, in / in, before administration, the lyophilized powder is dissolved in 1-2 ml of sterile water for injection, adults-1-3 ml of 5% solution (2-6 ml of 2.5% solution) per day, children-1-2 ml of 5% solution (2-4 ml of 2.5% solution) per day.
A11GB Ascorbic acid (Vitamin C) in combination with other drugs
