Symptoms: pallor of the skin, anorexia, nausea, vomiting, hepatonecrosis (the severity of necrosis directly depends on the degree of overdose).
Treatment: gastric lavage, activated charcoal.
Hypersensitivity to the components of the drug, gastrointestinal bleeding, portal hypertension, renal and hepatic insufficiency, glucose−6-phosphate dehydrogenase deficiency, pregnancy, breast-feeding, childhood (up to 6 years).
With caution — erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), blood diseases (thrombocytopenia, leukopenia, agranulocytosis), constitutional hyperbilirubinemia (Gilbert's syndrome), congenital hyperbilirubinemia (Dubin-Johnson syndrome and Rotor syndrome), alcoholism, old age.
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants, estrogen-containing contraceptives) increase the production of hydroxylated active metabolites, which leads to the possibility of severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis. Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects. Reduces the effectiveness of uricosuric drugs, increases the effect of drugs that depress the central nervous system, ethanol. If you slow down the emptying of the stomach (propantelin), it is possible to slow down the onset of the action of paracetamol, with acceleration (metoclopramide) - the drug begins to act faster. Increases the toxicity of chloramphenicol. Caution should be exercised with prolonged use of paracetamol and simultaneous therapy with oral drugs that inhibit blood clotting
Allergic reactions (skin rash, itching, urticaria, Quincke's edema), nausea, epigastric pain, anemia, thrombocytopenia, with prolonged use in high doses — hepatotoxic effect, nephrotoxic effect (renal colic, aseptic pyuria, interstitial nephritis, papillary necrosis), hemolytic and aplastic anemia, methemoglobinemia, pancytopenia, agranulocytosis, very rarely — a decrease in blood pressure, dyspnea.
Prolonged use of high doses of vitamin C can lead to the formation of oxalate stones in the kidneys.
APAP Przeziebienie® With
APAP Przeziebienie®
febrile syndrome in infectious and inflammatory diseases,
pain syndrome of moderate or mild severity (headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorrhea (painful irregular menstruation).
APAP Przeziebienie® Reno
acute allergic rhinitis (runny nose),
Acute respiratory infections with rhinitis,
sinusitis (inflammation of the mucous membrane of the paranasal sinuses),
pollinosis (allergic runny nose caused by plant pollen),
otitis media (inflammation of the middle ear) - to reduce swelling of the nasopharyngeal mucosa,
preparation of the patient for diagnostic manipulations in the nasal passages.
Pain syndrome of mild or moderate intensity (headache, neuralgia, myalgia, arthralgia, algodismenorrhea, toothache), a decrease in elevated body temperature in infectious and inflammatory diseases (including colds).
Pain syndrome of mild or moderate intensity (headache, neuralgia, myalgia, arthralgia, algodismenorrhea, toothache), a decrease in elevated body temperature in infectious and inflammatory diseases (including colds).
The mechanism of action of paracetamol is associated with the inhibition of the synthesis of PG and the predominant effect on the center of thermoregulation in the hypothalamus. Ascorbic acid (vitamin C) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, participates in the synthesis of glucocorticosteroids, collagen and procollagen, normalizes capillary permeability, increases the body's resistance, which is probably due to the antioxidant properties of ascorbic acid and the stimulation of the immune system.
APAP Przeziebienie® Reno
When applied topically, it is practically not absorbed, and plasma concentrations are so small that they cannot be determined by modern analytical methods.
APAP Przeziebienie
Sodium Ascorbate, Acetaminophen
Inside, after dissolving the contents of the bag in hot water or tea. Children 2-3 years — 1 bag in 50 ml, 4-6 years - 2 bags in 100 ml, 7-10 years-2-3 bags in 100-150 ml and 10-12 years-3 bags in 150 ml of hot water or tea every 4-6 hours, but no more than 5 times a day. The course is not more than 3 days.
