Nausea, dizziness, and vertigo were noted in healthy volunteers receiving 50 and 100 mg/kg doses of Antizol Vet (fomepizole) (at plasma concentrations of 290-520 µmol/L, 23.8-42.6 mg/L). These doses are 3-6 times the recommended dose. This dose-dependent CNS effect was short-lived in most subjects and lasted up to 30 hours in one subject.
Antizol Vet (fomepizole) is dialyzable, and hemodialysis may be useful in treating cases of overdosage.
Antizol Vet (fomepizole) should not be administered to patients with a documented serious hypersensitivity reaction to Antizol Vet (fomepizole) or other pyrazoles.
The most frequent adverse events reported as drug-related or unknown relationship to study drug in the 78 patients and 63 normal volunteers who received Antizol Vet® (fomepizole) Injection were headache (14%), nausea (11%), and dizziness, increased drowsiness, and bad taste/metallic taste (6% each). All other adverse events in this population were reported in approximately 3% or fewer of those receiving Antizol Vet (fomepizole) and were as follows:
Body as a Whole: Abdominal pain, fever, multiorgan system failure, pain during Antizol Vet (fomepizole) injection, inflammation at injection site, lumbalgia/backache, hangover
Cardiovascular: Sinus bradycardia/bradycardia, phlebosclerosis, tachycardia, phlebitis, shock, hypotension
Gastrointestinal: Vomiting, diarrhea, dyspepsia, heartburn, decreased appetite, transient transaminitis
Hemic/Lymphatic: Eosinophilia/hypereosinophilia, lymphangitis, disseminated intravascular coagulation, anemia
Nervous: Lightheadedness, seizure, agitation, feeling drunk, facial flush, vertigo, nystagmus, anxiety, "felt strange", decreased environmental awareness
Respiratory: Hiccups, pharyngitis
Skin/Appendages: Application site reaction, rash
Special Senses: Abnormal smell, speech/visual disturbances, transient blurred vision, roar in ear
Urogenital: Anuria
Antizol Vet (fomepizole) is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis (see DOSAGE AND ADMINISTRATION).
The plasma half-life of Antizol Vet (fomepizole) varies with dose, even in patients with normal renal function, and has not been calculated.
Distribution: After intravenous infusion, Antizol Vet (fomepizole) rapidly distributes to total body water. The volume of distribution is between 0.6 L/kg and 1.02 L/kg.
Metabolism: In healthy volunteers, only 1-3.5% of the administered dose of Antizol Vet (fomepizole) (7-20 mg/kg oral and IV) was excreted unchanged in the urine, indicating that metabolism is the major route of elimination. In humans, the primary metabolite of Antizol Vet (fomepizole) is 4-carboxypyrazole (approximately 80-85% of administered dose), which is excreted in the urine. Other metabolites of Antizol Vet (fomepizole) observed in the urine are 4-hydroxymethylpyrazole and the N-glucuronide conjugates of 4-carboxypyrazole and 4-hydroxymethylpyrazole.
Excretion: The elimination of Antizol Vet (fomepizole) is best characterized by Michaelis-Menten kinetics after acute doses, with saturable elimination occurring at therapeutic blood concentrations [100-300 µmol/L, 8.2-24.6 mg/L].
With multiple doses, Antizol Vet (fomepizole) rapidly induces its own metabolism via the cytochrome P450 mixed-function oxidase system, which produces a significant increase in the elimination rate after about 30-40 hours. After enzyme induction, elimination follows first-order kinetics.
No information provided.
PRECAUTIONS GeneralAntizol Vet (fomepizole) should not be given undiluted or by bolus injection. Venous irritation and phlebosclerosis were noted in two of six normal volunteers given bolus injections (over 5 minutes) of Antizol Vet (fomepizole) at a concentration of 25 mg/mL.
Minor allergic reactions (mild rash, eosinophilia) have been reported in a few patients receiving Antizol Vet (see ADVERSE REACTIONS). Therefore, patients should be monitored for signs of allergic reactions.
Laboratory TestsIn addition to specific antidote treatment with Antizol Vet (fomepizole) , patients intoxicated with ethylene glycol or methanol must be managed for metabolic acidosis, acute renal failure (ethylene glycol), adult respiratory distress syndrome, visual disturbances (methanol), and hypocalcemia. Fluid therapy and sodium bicarbonate administration are potential supportive therapies. In addition, potassium and calcium supplementation and oxygen administration are usually necessary. Hemodialysis is necessary in the anuric patient, or in patients with severe metabolic acidosis or azotemia (see DOSAGE AND ADMINISTRATION). Treatment success should be assessed by frequent measurements of blood gases, pH, electrolytes, BUN, creatinine, and urinalysis, in addition to other laboratory tests as indicated by individual patient conditions. At frequent intervals throughout the treatment, patients poisoned with ethylene glycol should be monitored for ethylene glycol concentrations in serum and urine, and the presence of urinary oxalate crystals. Similarly, serum methanol concentrations should be monitored in patients poisoned with methanol.
Electrocardiography should be performed because acidosis and electrolyte imbalances can affect the cardiovascular system. In the comatose patient, electroencephalography may also be required. In addition, hepatic enzymes and white blood cell counts should be monitored during treatment, as transient increases in serum transaminase concentrations and eosinophilia have been noted with repeated Antizol Vet (fomepizole) dosing.
Carcinogenesis, Mutagenesis, and Impairment of FertilityThere have been no long-term studies performed in animals to evaluate carcinogenic potential.
There was a positive Ames test result in the Escherichia coli tester strain WP2uvrA and the Salmonella typhimurium tester strain TA102 in the absence of metabolic activation. There was no evidence of a clastogenic effect in the in vivo mouse micronucleus assay.
In rats, fomepizole (110 mg/kg) administered orally for 40 to 42 days resulted in decreased testicular mass (approximately 8% reduction). This dose is approximately 0.6 times the human maximum daily exposure based on surface area (mg/m2). This reduction was similar for rats treated with either ethanol or fomepizole alone. When fomepizole was given in combination with ethanol, the decrease in testicular mass was significantly greater (approximately 30% reduction) compared to those rats treated exclusively with fomepizole or ethanol.
PregnancyPregnancy Category C: Animal reproduction studies have not been conducted with fomepizole. It is also not known whether Antizol Vet (fomepizole) can cause fetal harm when administered to pregnant women or can affect reproduction capacity. Antizol Vet (fomepizole) should be given to pregnant women only if clearly needed.
Nursing MothersIt is not known whether fomepizole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Antizol Vet (fomepizole) is administered to a nursing woman.
Pediatric UseSafety and effectiveness in pediatric patients have not been established.
Geriatric UseSafety and effectiveness in geriatric patients have not been established.
Treatment Guidelines: If ethylene glycol or methanol poisoning is left untreated, the natural progression of the poisoning leads to accumulation of toxic metabolites, including glycolic and oxalic acids (ethylene glycol intoxication) and formic acid (methanol intoxication). These metabolites can induce metabolic acidosis, nausea/vomiting, seizures, stupor, coma, calcium oxaluria, acute tubular necrosis, blindness, and death. The diagnosis of these poisonings may be difficult because ethylene glycol and methanol concentrations diminish in the blood as they are metabolized to their respective metabolites. Hence, both ethylene glycol and methanol concentrations and acid base balance, as determined by serum electrolyte (anion gap) and/or arterial blood gas analysis, should be frequently monitored and used to guide treatment.
Treatment consists of blocking the formation of toxic metabolites using inhibitors of alcohol dehydrogenase, such as Antizol Vet (fomepizole) , and correction of metabolic abnormalities. In patients with high ethylene glycol or methanol concentrations ( ≥ 50 mg/dL), significant metabolic acidosis, or renal failure, hemodialysis should be considered to remove ethylene glycol or methanol and the respective toxic metabolites of these alcohols.
Treatment with Antizol Vet (fomepizole) : Begin Antizol Vet (fomepizole) treatment immediately upon suspicion of ethylene glycol or methanol ingestion based on patient history and/or anion gap metabolic acidosis, increased osmolar gap, visual disturbances, or oxalate crystals in the urine, OR a documented serum ethylene glycol or methanol concentration greater than 20 mg/dL.
Hemodialysis: Hemodialysis should be considered in addition to Antizol Vet (fomepizole) in the case of renal failure, significant or worsening metabolic acidosis, or a measured ethylene glycol or methanol concentration of greater than or equal to 50 mg/dL. Patients should be dialyzed to correct metabolic abnormalities and to lower the ethylene glycol concentrations below 50 mg/dL.
Discontinuation of Antizol Vet (fomepizole) Treatment: Treatment with Antizol Vet (fomepizole) may be discontinued when ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH.
Dosing of Antizol Vet (fomepizole) : A loading dose of 15 mg/kg should be administered, followed by doses of 10 mg/kg every 12 hours for 4 doses, then 15 mg/kg every 12 hours thereafter until ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH. All doses should be administered as a slow intravenous infusion over 30 minutes (see Administration).
Dosage with Renal Dialysis: Antizol Vet® (fomepizole) Injection is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.
Antizol Vet (fomepizole) Dosing in Patients Requiring Hemodialysis
| DOSE AT THE BEGINNING OF HEMODIALYSIS | |
| If 6 hours since last Antizol Vet dose | If ≥ 6 hours since last Antizol Vet dose |
| Do not administer dose | Administer next scheduled dose |
| DOSING DURING HEMODIALYSIS | |
| Dose every 4 hours | |
| DOSING AT THE TIME HEMODIALYSIS IS COMPLETED | |
| Time between last dose and the end of hemodialysis | |
| 1 hour | Do not administer dose at the end of hemodialysis |
| 1–3 hours | Administer 1/2 of next scheduled dose |
| >3 hours | Administer next scheduled dose |
| MAINTENANCE DOSING OFF HEMODIALYSIS | |
| Give next scheduled dose 12 hours from last dose administered | |
Administration: Antizol Vet (fomepizole) solidifies at temperatures less than 25°C (77°F). If the Antizol Vet (fomepizole) solution has become solid in the vial, the solution should be liquefied by running the vial under warm water or by holding in the hand. Solidification does not affect the efficacy, safety, or stability of Antizol Vet (fomepizole). Using sterile technique, the appropriate dose of Antizol Vet (fomepizole) should be drawn from the vial with a syringe and injected into at least 100 mL of sterile 0.9% sodium chloride injection or dextrose 5% injection. Mix well. The entire contents of the resulting solution should be infused over 30 minutes. Antizol Vet (fomepizole) , like all parenteral products, should be inspected visually for particulate matter prior to administration.
Stability: Antizol Vet (fomepizole) diluted in 0.9% sodium chloride injection or dextrose 5% injection remains stable and sterile for at least 24 hours when stored refrigerated or at room temperature. Antizol Vet (fomepizole) does not contain preservatives. Therefore, maintain sterile conditions, and after dilution do not use beyond 24 hours. Solutions showing haziness, particulate matter, precipitate, discoloration, or leakage should not be used.
