31.12.1899 8:01:00

31.12.1899 8:01:00 Medicine

Contraindications

Hypersensitivity (including to other penicillins, cephalosporins and carbopenems).

Undesirable effects

Nausea, vomiting, diarrhea, allergic reactions (skin rash, itching, urticaria, erythema), rarely-a transient increase in the blood of hepatic transaminases, alkaline phosphatase.

Therapeutic indications

Infections (moderate and severe) of the lower respiratory tract, abdominal, skin and soft tissues (including cellulite, abscess, infected trophic ulcers), pelvic organs (including endometritis), bacterial infection in patients with neutropenia, septicemia, severe infectious and inflammatory diseases before identification of the pathogen.

Pharmacotherapeutic group

  • Penicillins in combinations

Pharmacodynamic properties

Active against (including beta-lactamase-producing) gram-negative aerobic bacteria (E. coli, Citrobacter, Klebsiella, Enterobacter, Proteus, Pseudomonas aeruginosa and other Pseudomonas, N. gonorrhoeae, Haemophilus inf.), gram-positive streptococci (S. pneumoniae, S. pyogenes, S. bovis, S. groups C and G), enterococci (E. faecalis, E. faecium), staphylococci (St. aureus, St. epidermidis), anaerobic microorganisms (Bacteroides, B. fragilis, B. ovatus, Fusobacteria).

Name of the medicinal product

31.12.1899 8:01:00

Qualitative and quantitative composition

Piperacillin, Tazobactam

Dosage (Posology) and method of administration

In/in (2.25 g is dissolved in 5 ml of saline solution or 5% dextrose solution, or sterile water for injection), slowly, for 30 minutes. Adults and children over 12 years of age — 2.25 g every 6 hours or 4.5 g every 8 hours (the average daily dose is 12 g of piperacillin and 1.5 g of tazobactam), patients on hemodialysis-2.25 g every 8 hours. The course is 7-10 days.